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M170 Next Generation Impactor
Design and Performance The effort involved in the operation of cascade impactors and the uncertainty in the particle size distribution results have long been a source of concern for those involved in the testing of pharmaceutical inhalers. For this reason, in 1997, a group of prominent pharmaceutical companies involved in the development and manufacture of inhalers asked MSP to develop a new impactor specifically designed for testing pharmaceutical inhalers using the very latest design theory. The result, the Next Generation Impactor (NGI), was launched in 2000.
The NGI is a high-performance, precision, particle classifying cascade impactor designed for testing MDIs, DPIs, nebulizers and aerosol and nasal sprays. Calibrations to document the stage cut-off aerodynamic diameters at 15, 30, 60 and 100 L/min were conducted according to pharmaceutical standards. The NGI has seven stages plus a micro-orifice collector (MOC) and its main features include:
- Designed by and for the pharma industry
- Meets and exceeds all USP and EP specifications
- State of the art aerodynamic performance
- Operates at any flow rate between 15 and 100 L/min
- Particle size range covered: 0.24 to 11.7 microns (dependent on flow rate)
- 7 stages total with 5 stages always in the cut-off range between 0.54 and 6.12 microns
- Corrosion resistant construction
- Electrically conductive; unaffected by static
- Excellent accuracy, reproducibility and stage efficiency: all stages 500 < Re < 3000
- Easy drug recovery with low inter-stage losses
- Comprised of just 3 main parts to lend itself to practical semi and full automation
- Monographs incorporated both into the USP and EP
Today, its accuracy, ease of use and high productivity is making the NGI the new “workhorse” of the pharmaceutical industry.