|
THE
NEXT GENERATION PHARMACEUTICAL IMPACTOR (NGI)
 |
 |
| NGI with
Induction Port and Pre-Separator |
NGI - Showing Nozzles
and
Cup Tray
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The Model 170 Next Generation Pharmaceutical
Impactor (NGI) is a high-performance, precision, particle-classifying
cascade impactor for testing metered-dose, dry-powder, and
similar inhaler devices. MSP developed this impactor in conjunction
with a 15-member consortium of pharmaceutical companies (Next
Generation Impactor Consortium). Substantial
user-involvement
in the design process has resulted in a combination of aerodynamic
design principles and user-friendly operation. A removable
set of collection cups minimizes the time between inhaler
tests. Other time-saving features include the absence of a
final filter and of inlet O-rings. The NGI has been tested
by 15 pharmaceutical companies in the NGI Consortium.
APPLICATIONS
- Development of metered-dose or dry-powder
inhalers
-
QA/QC testing of commercial
inhaler products
FEATURES
- Designed for productivity
- Hinged lid that is easy to open
- Easy to recover samples from cups
- Easy to prepare for next test
- Removable set of collection cups
- Micro-orifice collector in place of final
filter
- O-ring free inlet
- Electrically conductive and corrosion-resistant
- Functions over wide flow range (30 L/min to 100 L/min)
- Incorporates state-of-the-art aerodynamic
principles
- Meets USP System Suitability standards
- Sizes particles between 0.23 µm and
11 µm depending on the flowrate
- Seven stages: at lease five with D50 values
between 0.5 µm and 6.5 µm at all flow rates
- Calibrated with particles at 60 L/min flow
rate
- Low internal particles losses; minimal washing
between tests
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NGI CHARACTERISTICS |
| Stage |
1 |
2 |
3 |
4 |
5 |
6 |
7 |
| D50 Diameter, µm, at flow
rate |
|
|
|
|
|
|
|
| 30 L/min* |
11.7 |
6.40 |
3.99 |
2.30 |
1.36 |
0.83 |
0.54 |
| 60 L/min* |
8.06 |
4.46 |
2.82 |
1.66 |
0.94 |
0.55 |
0.34 |
| 100 L/min* |
6.12 |
3.42 |
2.18 |
1.31 |
0.72 |
0.40 |
0.24 |
|
*
Experimentally Determined
see: Marple, V. A.; Olson, B.; Santhanakrishnan, K.;
Mitchell, J.P.; Murray, S.C.;
Hudson-Curtis, B.L.; "Next Generation Pharmaceutical
Impactor (A New Impactor
for Pharmaceutical Inhaler Testing). Part II: Archival
Calibration" Journal
of Aerosol Medicine; Vol. 16; Number 3; 2003; pp. 301-324.
For a complimentary reprint of this article, email
sales@mspcorp.com.
|
ACCESSORIES |
| Automated Rinsers,
USP Inlet, Pre-Separator, Vacuum Pump, Flow Meter,
Timed Flow Controller, Filter Holder, Leak Tester |
|
|
SPECIFICATIONS |
| Flow Rate |
30 L/min to 100 L/min air flow
Particle size fractionation range 0.23µm
to 11 µm |
| Weight |
9 Kg |
|
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